PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus. [electronic resource]
Producer: 20141028Description: 1581-8 p. digitalISSN:- 1791-2431
- Antineoplastic Agents -- pharmacology
- Blotting, Western
- Cell Line, Tumor
- Chromones -- pharmacology
- Enzyme Activation -- drug effects
- Humans
- Morpholines -- pharmacology
- Multiple Myeloma -- metabolism
- Oncogene Protein v-akt -- antagonists & inhibitors
- Oncolytic Virotherapy -- methods
- Oncolytic Viruses
- Phosphoinositide-3 Kinase Inhibitors
- Real-Time Polymerase Chain Reaction
- Signal Transduction -- drug effects
- TNF-Related Apoptosis-Inducing Ligand -- metabolism
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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