The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. [electronic resource]
Producer: 20141021Description: e1061 p. digitalISSN:- 2041-4889
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Proliferation
- DEAD-box RNA Helicases -- genetics
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Interferon-alpha -- pharmacology
- Janus Kinase 1 -- metabolism
- Melanoma -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Neoplasm Proteins -- genetics
- Neoplastic Stem Cells -- drug effects
- Nuclear Proteins -- genetics
- Phosphorylation
- Promyelocytic Leukemia Protein
- RNA Interference
- RNA, Messenger -- metabolism
- STAT Transcription Factors -- metabolism
- Signal Transduction -- drug effects
- Skin Neoplasms -- drug therapy
- Spheroids, Cellular
- Suppressor of Cytokine Signaling 1 Protein
- Suppressor of Cytokine Signaling Proteins -- genetics
- TYK2 Kinase -- metabolism
- Time Factors
- Transcription Factors -- genetics
- Transfection
- Tumor Burden
- Tumor Suppressor Proteins -- genetics
- Ubiquitination
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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