Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells. [electronic resource]
Producer: 20140627Description: 26-34 p. digitalISSN:- 1096-0007
- Anticonvulsants -- pharmacology
- Antioxidants -- metabolism
- Apoptosis -- drug effects
- Blotting, Western
- Calcium -- metabolism
- Catalase -- metabolism
- Cells, Cultured
- DNA Methylation
- Endoplasmic Reticulum -- drug effects
- Epithelial Cells -- drug effects
- Glutathione Reductase -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Kelch-Like ECH-Associated Protein 1
- Lens, Crystalline -- cytology
- NF-E2-Related Factor 2 -- metabolism
- Oxidative Stress -- drug effects
- Promoter Regions, Genetic -- drug effects
- RNA, Messenger -- metabolism
- Reactive Oxygen Species -- metabolism
- Real-Time Polymerase Chain Reaction
- Valproic Acid -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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