Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin. [electronic resource]
Producer: 20140908Description: 17 p. digitalISSN:- 1476-4598
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Electrophoretic Mobility Shift Assay
- Fluorescent Antibody Technique
- Humans
- Hypereosinophilic Syndrome -- genetics
- Imidazoles -- pharmacology
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Microscopy, Electron, Transmission
- Molecular Docking Simulation
- Myeloid Cell Leukemia Sequence 1 Protein -- metabolism
- Oncogene Proteins, Fusion -- genetics
- Pyridazines -- pharmacology
- Receptor, Platelet-Derived Growth Factor alpha -- genetics
- Transfection
- Xenograft Model Antitumor Assays
- beta Catenin -- metabolism
- mRNA Cleavage and Polyadenylation Factors -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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