Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain. [electronic resource]
Producer: 20141030Description: 191-212 p. digitalISSN:- 1875-8908
- Age Factors
- Alzheimer Disease -- drug therapy
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Brain -- metabolism
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Ferric Compounds
- Humans
- Imaging, Three-Dimensional
- Metal Nanoparticles
- Mice
- Mice, Transgenic
- Microglia -- metabolism
- Mutation -- genetics
- NF-kappa B -- metabolism
- Neuroprotective Agents -- chemistry
- Plaque, Amyloid -- pathology
- Presenilin-1 -- genetics
- Resveratrol
- Stilbenes -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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