Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. [electronic resource]
Producer: 20150219Description: 468-74 p. digitalISSN:- 1538-8514
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Colonic Neoplasms -- genetics
- Cytokine Receptor gp130 -- genetics
- Disease Progression
- Epithelium -- drug effects
- Gastrointestinal Neoplasms -- genetics
- Gene Expression -- drug effects
- Humans
- Immunohistochemistry
- Janus Kinase 1 -- antagonists & inhibitors
- Janus Kinase 2 -- antagonists & inhibitors
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Proliferating Cell Nuclear Antigen -- metabolism
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- STAT3 Transcription Factor -- genetics
- Tumor Burden -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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