A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. [electronic resource]
Producer: 20140325Description: 1171-83 p. digitalISSN:- 1550-6606
- Adaptor Proteins, Signal Transducing -- physiology
- Animals
- Apoptosis -- physiology
- Caspase 3 -- metabolism
- Caspase 8 -- physiology
- Cytopathogenic Effect, Viral -- physiology
- DEAD-box RNA Helicases -- physiology
- Enzyme Activation
- Fas-Associated Death Domain Protein -- physiology
- Fibroblasts -- virology
- HEK293 Cells -- virology
- HeLa Cells -- virology
- Humans
- Interferon-Induced Helicase, IFIH1
- Mice
- Mitochondria -- enzymology
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA Interference
- RNA, Viral -- genetics
- Semliki forest virus -- physiology
- Signal Transduction
- Virus Replication
- bcl-X Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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