Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. [electronic resource]
Producer: 20140415Description: 946-57 p. digitalISSN:- 1532-1827
- Animals
- Antimetabolites, Antineoplastic -- pharmacology
- Apoptosis Regulatory Proteins
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Proliferation
- Cell Survival -- genetics
- Chromones -- pharmacology
- Colorectal Neoplasms -- drug therapy
- Drug Resistance, Neoplasm -- genetics
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Fluorouracil -- pharmacology
- Humans
- Inhibitor of Apoptosis Proteins -- biosynthesis
- Mice
- Mice, Inbred BALB C
- Morpholines -- pharmacology
- Neoplasm Invasiveness
- Neoplasm Metastasis -- genetics
- Neoplasm Transplantation
- Neovascularization, Pathologic -- genetics
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Repressor Proteins -- biosynthesis
- Retinoblastoma Protein -- metabolism
- Smad4 Protein -- deficiency
- Survivin
- Up-Regulation
- Vascular Endothelial Growth Factor A -- metabolism
- Wound Healing
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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