Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole. [electronic resource]
Producer: 20140416Description: 107-15 p. digitalISSN:- 0006-3002
- Blotting, Western
- Caco-2 Cells
- Chelating Agents -- pharmacology
- Cytochrome P-450 CYP1A1 -- genetics
- Egtazic Acid -- analogs & derivatives
- Enzyme Inhibitors -- pharmacology
- Hep G2 Cells
- Humans
- MCF-7 Cells
- Models, Genetic
- Okadaic Acid -- pharmacology
- Omeprazole -- pharmacology
- Phosphorylation -- drug effects
- Polychlorinated Dibenzodioxins -- pharmacology
- Promoter Regions, Genetic -- genetics
- Protein Binding
- Protein Phosphatase 2 -- antagonists & inhibitors
- Proton Pump Inhibitors -- pharmacology
- RNA Interference
- Receptors, Aryl Hydrocarbon -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Serine -- metabolism
- Sp1 Transcription Factor -- metabolism
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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