TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. [electronic resource]
Producer: 20140422Description: 4653-9 p. digitalISSN:- 1083-351X
- Amyotrophic Lateral Sclerosis -- genetics
- Base Sequence
- C9orf72 Protein
- DNA Repeat Expansion -- genetics
- Frontotemporal Dementia -- genetics
- G-Quadruplexes -- drug effects
- Heterogeneous Nuclear Ribonucleoprotein A1
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B -- metabolism
- Humans
- Nuclear Proteins -- metabolism
- Porphyrins -- chemistry
- Protein Binding -- drug effects
- Proteins -- genetics
- RNA-Binding Proteins -- metabolism
- Serine-Arginine Splicing Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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