Induction of apoptosis in cholangiocarcinoma by an andrographolide analogue is mediated through topoisomerase II alpha inhibition. [electronic resource]
Producer: 20141007Description: 148-55 p. digitalISSN:- 1879-0712
- Antigens, Neoplasm
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Bile Duct Neoplasms -- metabolism
- Caspase 3 -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cholangiocarcinoma -- metabolism
- Cyclooxygenase 2 -- metabolism
- DNA -- metabolism
- DNA Topoisomerases, Type II
- DNA-Binding Proteins -- antagonists & inhibitors
- Diterpenes -- pharmacology
- Humans
- Organosilicon Compounds -- pharmacology
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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