Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation. [electronic resource]
Producer: 20140930Description: e81937 p. digitalISSN:- 1932-6203
- Animals
- Cell Line, Tumor
- Cell Transformation, Neoplastic -- genetics
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA (Cytosine-5-)-Methyltransferases -- genetics
- DNA Methylation
- MAP Kinase Signaling System -- genetics
- Melanocytes -- metabolism
- Melanoma -- genetics
- Mice
- Signal Transduction -- genetics
- Superoxides -- metabolism
- rac1 GTP-Binding Protein -- genetics
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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