ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition. [electronic resource]
Producer: 20141121Description: 317-28 p. digitalISSN:- 1555-8576
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Clone Cells -- drug effects
- Drug Synergism
- ErbB Receptors -- genetics
- Erlotinib Hydrochloride
- Flavonoids -- pharmacology
- Furans -- pharmacology
- Head and Neck Neoplasms
- Humans
- Lung Neoplasms
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Oncogene Protein v-akt -- metabolism
- Phosphatidylinositol 3-Kinase -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins p21(ras)
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- Quinazolines -- pharmacology
- Signal Transduction -- genetics
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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