Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. [electronic resource]
Producer: 20141001Description: 619-28 p. digitalISSN:- 1873-3913
- Adjuvants, Immunologic -- pharmacology
- Antibodies -- immunology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival
- Colforsin -- pharmacology
- Cyclic AMP -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- chemistry
- GTP-Binding Proteins
- HEK293 Cells
- HeLa Cells
- Hep G2 Cells
- Humans
- Immunologic Factors -- pharmacology
- Interferon-alpha -- pharmacology
- Interferon-beta -- pharmacology
- Janus Kinase 1 -- antagonists & inhibitors
- Luteolin -- pharmacology
- Neoplasm Proteins
- Phosphodiesterase Inhibitors -- pharmacology
- Phosphoric Diester Hydrolases -- metabolism
- Phosphorylation -- drug effects
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- antagonists & inhibitors
- Receptor, Interferon alpha-beta -- chemistry
- Receptors for Activated C Kinase
- Receptors, Cell Surface
- STAT1 Transcription Factor -- antagonists & inhibitors
- STAT2 Transcription Factor -- antagonists & inhibitors
- Signal Transduction -- drug effects
- TYK2 Kinase -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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