Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. [electronic resource]
Producer: 20140303Description: 346-58 p. digitalISSN:- 1521-0103
- Amino Acid Substitution
- Binding Sites -- drug effects
- Cell Line
- Cytosol -- metabolism
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Excitatory Amino Acid Antagonists -- adverse effects
- Hallucinogens -- adverse effects
- Humans
- Hydrogen-Ion Concentration
- Ibogaine -- adverse effects
- Ion Channel Gating -- drug effects
- Kinetics
- Membrane Potentials -- drug effects
- Membrane Transport Modulators -- pharmacology
- Molecular Conformation
- Molecular Docking Simulation
- Mutant Proteins -- agonists
- Narcotic Antagonists -- adverse effects
- Nerve Tissue Proteins -- antagonists & inhibitors
- Recombinant Proteins -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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