Pathologic complete response after preoperative anti-HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling. [electronic resource]
Producer: 20140714Description: 507 p. digitalISSN:- 1756-0500
- Adult
- Aged
- Antibodies, Monoclonal, Humanized -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols
- Autophagy
- Biomarkers, Pharmacological
- Breast Neoplasms -- drug therapy
- Carcinoma, Ductal, Breast -- drug therapy
- Drug Administration Schedule
- Female
- Forkhead Box Protein O1
- Forkhead Transcription Factors -- genetics
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Lapatinib
- Middle Aged
- Neoadjuvant Therapy -- methods
- PTEN Phosphohydrolase -- genetics
- Paclitaxel -- administration & dosage
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphorylation
- Quinazolines -- administration & dosage
- Receptor, ErbB-2 -- antagonists & inhibitors
- STAT5 Transcription Factor -- genetics
- Signal Transduction -- drug effects
- Trastuzumab
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Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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