Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor α transactivation. [electronic resource]
Producer: 20141014Description: 89-103 p. digitalISSN:- 1096-0929
- Aryl Hydrocarbon Hydroxylases -- genetics
- Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics
- Base Sequence
- Cytochrome P-450 CYP1B1
- Deoxyribonucleases
- Estradiol -- pharmacology
- Estrogen Receptor alpha -- genetics
- Gene Deletion
- Gene Knockdown Techniques
- Humans
- Ligands
- MCF-7 Cells
- Molecular Sequence Data
- Polychlorinated Dibenzodioxins -- pharmacology
- Protein Multimerization
- Receptor Cross-Talk
- Receptors, Aryl Hydrocarbon -- genetics
- Transcriptional Activation -- drug effects
- Zinc Fingers
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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