Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. [electronic resource]
Producer: 20141121Description: 303-14 p. digitalISSN:- 1551-4005
- Carbolines -- pharmacology
- Caspases -- metabolism
- Cell Cycle Proteins -- metabolism
- Cell Death -- drug effects
- Cell Line, Tumor
- Checkpoint Kinase 1
- Chromosomes, Human -- genetics
- DNA Fragmentation -- drug effects
- Deoxycytidine -- analogs & derivatives
- Enzyme Activation
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Mitosis -- drug effects
- Nuclear Proteins -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein Kinases -- metabolism
- Protein-Tyrosine Kinases -- metabolism
- Rad51 Recombinase -- metabolism
- S Phase Cell Cycle Checkpoints -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Gemcitabine
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Publication Type: Journal Article
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