DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells. [electronic resource]
Producer: 20140218Description: 395-406 p. digitalISSN:- 1879-3169
- Anisomycin -- toxicity
- Apoptosis -- drug effects
- Carcinogens -- toxicity
- Cell Survival -- drug effects
- Chromosome Mapping
- Data Interpretation, Statistical
- Endoplasmic Reticulum Stress -- drug effects
- Gene Expression Profiling
- Heat-Shock Proteins -- metabolism
- Humans
- Ionomycin -- pharmacology
- Jurkat Cells
- Microarray Analysis
- Mitochondrial Proteins -- metabolism
- NF-E2-Related Factor 2 -- metabolism
- Nucleic Acid Synthesis Inhibitors -- toxicity
- RNA, Neoplasm -- biosynthesis
- T-Lymphocytes -- drug effects
- Thapsigargin -- toxicity
- Trialkyltin Compounds -- toxicity
- Trichothecenes -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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