A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. [electronic resource]
Producer: 20140819Description: 868-77 p. digitalISSN:- 2211-1247
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- genetics
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Cell Proliferation
- Cisplatin -- pharmacology
- DNA Damage -- genetics
- DNA Repair -- genetics
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Protein Serine-Threonine Kinases -- genetics
- RNA Interference
- RNA, Small Interfering
- Tumor Suppressor Protein p53 -- genetics
- p38 Mitogen-Activated Protein Kinases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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