Polysaccharide-specific memory B cells generated by conjugate vaccines in humans conform to the CD27+IgG+ isotype-switched memory B Cell phenotype and require contact-dependent signals from bystander T cells activated by bacterial proteins to differentiate into plasma cells. [electronic resource]
Producer: 20140218Description: 6071-83 p. digitalISSN:- 1550-6606
- Antigen Presentation
- Antigens, Bacterial -- immunology
- B-Lymphocyte Subsets -- immunology
- Bystander Effect -- immunology
- Humans
- Immunoglobulin Class Switching
- Immunoglobulin G -- analysis
- Immunologic Memory -- immunology
- Immunophenotyping
- Leukocytes, Mononuclear -- immunology
- Lymphocyte Activation
- Lymphocyte Cooperation
- Lymphopoiesis -- immunology
- Models, Immunological
- Neisseria meningitidis, Serogroup C -- immunology
- Palatine Tonsil -- immunology
- Plasma Cells -- cytology
- Polysaccharides, Bacterial -- immunology
- Receptors, Antigen, B-Cell -- immunology
- T-Lymphocyte Subsets -- immunology
- Tetanus Toxoid -- immunology
- Tumor Necrosis Factor Receptor Superfamily, Member 7 -- analysis
- Vaccines, Conjugate -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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