Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down. [electronic resource]
Producer: 20140811Description: 10-22 p. digitalISSN:- 1873-569X
- Basic Helix-Loop-Helix Transcription Factors -- agonists
- Cell Differentiation -- drug effects
- Cells, Cultured
- Chloracne -- etiology
- Cytochrome P-450 CYP1A1 -- biosynthesis
- Dose-Response Relationship, Drug
- Enzyme Induction
- Epidermis -- drug effects
- Filaggrin Proteins
- Gene Knockdown Techniques
- Humans
- Indoles -- toxicity
- Intermediate Filament Proteins -- metabolism
- Keratinocytes -- drug effects
- Ligands
- Phenotype
- Polychlorinated Dibenzodioxins -- toxicity
- Protein Precursors -- metabolism
- RNA Interference
- Receptors, Aryl Hydrocarbon -- agonists
- Thiazoles -- toxicity
- Transfection
- Transglutaminases -- metabolism
- beta-Naphthoflavone -- toxicity
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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