The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. [electronic resource]
Producer: 20140515Description: 1991-2002 p. digitalISSN:- 1097-0215
- Antineoplastic Agents -- pharmacology
- Ataxia Telangiectasia Mutated Proteins -- drug effects
- Benzofurans -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1
- Checkpoint Kinase 2 -- genetics
- DNA Damage -- drug effects
- HCT116 Cells
- HT29 Cells
- Hep G2 Cells
- Humans
- Jurkat Cells
- Leukemia -- drug therapy
- MCF-7 Cells
- Phosphorylation -- drug effects
- Plant Extracts -- pharmacology
- Protein Biosynthesis -- drug effects
- Protein Kinases -- genetics
- RNA Interference
- RNA, Small Interfering
- S Phase Cell Cycle Checkpoints -- drug effects
- T-Lymphocytes -- drug effects
- cdc25 Phosphatases -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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