Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties. [electronic resource]
Producer: 20140318Description: 8803-13 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Design
- ErbB Receptors -- antagonists & inhibitors
- Heterocyclic Compounds, 2-Ring -- chemical synthesis
- Humans
- Male
- Mice
- Mice, SCID
- Molecular Structure
- Pyrimidines -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Solubility
- Structure-Activity Relationship
- Thermodynamics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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