Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. [electronic resource]
Producer: 20150115Description: 258-69 p. digitalISSN:- 1476-5403
- Animals
- Apoptosis -- drug effects
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Drug
- Glioblastoma -- metabolism
- Humans
- Male
- Mice
- Mice, Nude
- Neoplastic Stem Cells -- drug effects
- Phenotype
- Phthalazines -- pharmacology
- Piperazines -- pharmacology
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- metabolism
- Reactive Oxygen Species -- metabolism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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