Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. [electronic resource]
Producer: 20140826Description: 389-402 p. digitalISSN:- 1476-5381
- Animals
- Biological Availability
- Brain -- metabolism
- Calcium -- metabolism
- Cell Hypoxia
- Chlormethiazole -- analogs & derivatives
- Chromatography, High Pressure Liquid
- Excitatory Amino Acid Agonists -- toxicity
- Female
- GABA Agonists -- pharmacology
- Glucose -- deficiency
- Glutamic Acid -- metabolism
- Mice
- Mice, Inbred C57BL
- N-Methylaspartate -- toxicity
- Nerve Degeneration -- prevention & control
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Oocytes -- drug effects
- Pregnancy
- Primary Cell Culture
- Rats
- Rats, Sprague-Dawley
- Receptors, GABA-A -- drug effects
- Xenopus laevis
- gamma-Aminobutyric Acid -- pharmacology
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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