Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. [electronic resource]
Producer: 20140828Description: 1436-48 p. digitalISSN:- 1476-5381
- Adenocarcinoma -- drug therapy
- Adenocarcinoma of Lung
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Benzylidene Compounds -- pharmacology
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- Fluorodeoxyglucose F18
- Gene Expression Regulation, Neoplastic
- Humans
- Inflammation Mediators -- metabolism
- Ki-67 Antigen -- metabolism
- Lung Neoplasms -- drug therapy
- Male
- Mice
- Mice, Nude
- Multimodal Imaging
- Phosphorylation
- Piperidones -- pharmacology
- Positron-Emission Tomography
- Signal Transduction -- drug effects
- Time Factors
- Tomography, X-Ray Computed
- Transcription Factor RelA -- genetics
- Transfection
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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