RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. [electronic resource]
Producer: 20140623Description: 463 p. digitalISSN:- 1471-2407
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents -- pharmacology
- Camptothecin -- pharmacology
- Colonic Neoplasms -- genetics
- Cytokine Receptor gp130 -- metabolism
- Female
- Gene Expression
- Humans
- Interleukin-6 -- metabolism
- Janus Kinases -- metabolism
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Organoplatinum Compounds -- pharmacology
- Oxaliplatin
- Phosphatidylethanolamine Binding Protein -- metabolism
- Phosphorylation -- drug effects
- Prognosis
- Protein Binding
- STAT3 Transcription Factor -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Transcription, Genetic
- Tumor Burden
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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