AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53. [electronic resource]
Producer: 20140527Description: 397-408 p. digitalISSN:- 1573-7217
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Aurora Kinase A -- antagonists & inhibitors
- Aurora Kinase B -- antagonists & inhibitors
- Aurora Kinase C -- antagonists & inhibitors
- Breast Neoplasms
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- DNA Copy Number Variations
- DNA Mutational Analysis
- Drug Screening Assays, Antitumor
- Female
- Gene Expression
- Humans
- Mutation
- Phthalazines -- pharmacology
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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