Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. [electronic resource]
Producer: 20140120Description: 32343-32356 p. digitalISSN:- 1083-351X
- Antineoplastic Agents -- pharmacology
- Apoptosis Regulatory Proteins -- biosynthesis
- Cell Line, Tumor
- Cell Survival
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- genetics
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Limonins -- pharmacology
- MAP Kinase Signaling System -- drug effects
- Neoplasms -- drug therapy
- Reactive Oxygen Species -- metabolism
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- genetics
- Response Elements
- TNF-Related Apoptosis-Inducing Ligand -- pharmacology
- Transcription Factor CHOP -- genetics
- Tumor Suppressor Protein p53 -- genetics
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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