Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy. [electronic resource]
Producer: 20140804Description: 2847-56 p. digitalISSN:- 1538-8514
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Endometrial Neoplasms -- genetics
- Female
- Gene Silencing
- Humans
- Metformin -- pharmacology
- Mice
- Mutation
- PTEN Phosphohydrolase -- genetics
- Protein Kinase C -- metabolism
- Protein Transport
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins p21(ras)
- Signal Transduction -- drug effects
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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