Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70. [electronic resource]
Producer: 20140120Description: 32622-32636 p. digitalISSN:- 1083-351X
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- genetics
- Aspartic Acid -- genetics
- Biological Transport, Active -- drug effects
- Cyclosporine -- pharmacology
- Endoplasmic Reticulum -- genetics
- HSP70 Heat-Shock Proteins -- genetics
- HeLa Cells
- Humans
- Immunosuppressive Agents -- pharmacology
- Mutation
- Protein Folding -- drug effects
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Tacrolimus -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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