Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. [electronic resource]
Producer: 20140312Description: e804 p. digitalISSN:- 2041-4889
- 3-Phosphoinositide-Dependent Protein Kinases -- metabolism
- Adenosine Triphosphate -- metabolism
- Animals
- Antineoplastic Agents -- chemistry
- Autophagy -- drug effects
- Carcinoma
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Disease Models, Animal
- Down-Regulation -- drug effects
- Drug Screening Assays, Antitumor
- Energy Metabolism -- drug effects
- Glucose -- metabolism
- Hexokinase -- metabolism
- Mice
- Mice, Nude
- Models, Biological
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms -- drug therapy
- Necrosis
- Neoplasms -- drug therapy
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Sesquiterpenes -- chemistry
- Signal Transduction -- drug effects
- Substrate Specificity -- drug effects
- Treatment Outcome
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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