Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus. [electronic resource]
Producer: 20140408Description: e74956 p. digitalISSN:- 1932-6203
- 5' Untranslated Regions -- genetics
- 5-Methylcytosine -- analogs & derivatives
- Adolescent
- Adult
- CCCTC-Binding Factor
- Cerebellum -- metabolism
- Cytosine -- analogs & derivatives
- DNA Methylation
- Friedreich Ataxia -- genetics
- Genetic Loci
- Humans
- Iron-Binding Proteins -- genetics
- Microsatellite Repeats
- Middle Aged
- Myocardium -- metabolism
- Protein Binding
- Repressor Proteins -- metabolism
- Young Adult
- Frataxin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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