Hydronephrotic urine in the obstructed kidney promotes urothelial carcinoma cell proliferation, migration, invasion through the activation of mTORC2-AKT and ERK signaling pathways. [electronic resource]
Producer: 20140408Description: e74300 p. digitalISSN:- 1932-6203
- Animals
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation
- Cell Survival -- drug effects
- Epidermal Growth Factor -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Expression Regulation, Neoplastic -- drug effects
- Hydronephrosis -- therapy
- Male
- Mechanistic Target of Rapamycin Complex 2
- Multiprotein Complexes -- metabolism
- Neoplasm Invasiveness
- Neovascularization, Pathologic
- Proto-Oncogene Proteins c-akt -- metabolism
- Rats
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Urologic Neoplasms -- blood supply
- Urothelium -- pathology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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