Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer. [electronic resource]
Producer: 20140116Description: 159-66 p. digitalISSN:- 1872-7980
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Carcinoma, Non-Small-Cell Lung -- blood supply
- Cell Line, Tumor -- drug effects
- Cell Proliferation -- drug effects
- Chick Embryo
- Chorioallantoic Membrane -- blood supply
- Drug Screening Assays, Antitumor -- methods
- Drug Synergism
- G1 Phase Cell Cycle Checkpoints
- Gene Expression -- drug effects
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Indoles -- pharmacology
- Inhibitory Concentration 50
- Lung Neoplasms -- blood supply
- Phosphorylation
- Protein Processing, Post-Translational -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyrroles -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
- Sirolimus -- pharmacology
- Sunitinib
- TOR Serine-Threonine Kinases -- metabolism
- Tissue Culture Techniques
- Vascular Endothelial Growth Factor A -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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