Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. [electronic resource]
Producer: 20140116Description: 139-49 p. digitalISSN:- 1872-7980
- 3' Untranslated Regions
- Animals
- Antibodies, Monoclonal, Humanized -- pharmacology
- Antineoplastic Agents -- pharmacology
- Base Sequence
- Binding Sites
- Brain Neoplasms -- drug therapy
- Cell Line, Tumor
- ErbB Receptors -- antagonists & inhibitors
- Feedback, Physiological
- Gene Expression Regulation, Neoplastic
- Glioblastoma -- drug therapy
- Humans
- Mice
- Mice, Nude
- MicroRNAs -- genetics
- Neoplasm Invasiveness
- PPAR alpha -- genetics
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA Interference
- Transcription Factor AP-1 -- metabolism
- Tumor Burden
- Von Hippel-Lindau Tumor Suppressor Protein -- metabolism
- Wnt Signaling Pathway
- Xenograft Model Antitumor Assays
- beta Catenin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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