Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo. [electronic resource]
Producer: 20140407Description: 2449-57 p. digitalISSN:- 1791-2431
- Aminoimidazole Carboxamide -- analogs & derivatives
- Animals
- Carcinoma, Hepatocellular -- drug therapy
- Cell Survival -- drug effects
- Cyclin D1 -- biosynthesis
- Cyclin-Dependent Kinase Inhibitor p21 -- biosynthesis
- Cyclin-Dependent Kinase Inhibitor p27 -- biosynthesis
- Gene Expression Regulation, Neoplastic -- drug effects
- Hep G2 Cells
- Humans
- Liver Neoplasms -- drug therapy
- Metformin -- pharmacology
- Mice
- Ribonucleotides -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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