Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition. [electronic resource]
Producer: 20140310Description: 7939-50 p. digitalISSN:- 1520-4804
- Catalytic Domain
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Diphosphates -- chemistry
- Diphosphonates -- chemistry
- Enzyme Inhibitors -- chemistry
- Geranyltranstransferase -- antagonists & inhibitors
- Humans
- Models, Molecular
- Molecular Structure
- Protein Binding
- Protein Conformation
- Protein Structure, Tertiary
- Pyrimidines -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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