PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment. [electronic resource]
Producer: 20140718Description: 1383-97 p. digitalISSN:- 1432-1440
- Apoptosis -- drug effects
- Biphenyl Compounds -- pharmacology
- Bone Marrow -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Coculture Techniques
- Drug Synergism
- Gene Expression Regulation, Leukemic
- Humans
- Hypoxia -- metabolism
- Indazoles -- pharmacology
- Leukemia, Myeloid, Acute -- genetics
- Mesenchymal Stem Cells -- drug effects
- Myeloid Cell Leukemia Sequence 1 Protein -- genetics
- Nitrophenols -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Piperazines -- pharmacology
- RNA Interference
- Sulfonamides -- pharmacology
- Tumor Microenvironment -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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