O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells. [electronic resource]
Producer: 20140401Description: e69150 p. digitalISSN:- 1932-6203
- Acetylglucosamine -- analogs & derivatives
- Antineoplastic Agents, Hormonal -- pharmacology
- Biosynthetic Pathways
- Breast Neoplasms -- genetics
- Cell Death -- drug effects
- Drug Resistance, Neoplasm -- genetics
- Estrogen Receptor alpha -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Hexosamines -- biosynthesis
- Humans
- Insulin-Like Growth Factor I -- pharmacology
- MCF-7 Cells
- Oximes -- pharmacology
- Phenylcarbamates -- pharmacology
- Phosphatidylinositol 3-Kinases -- metabolism
- Promoter Regions, Genetic
- Protein Processing, Post-Translational -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Selective Estrogen Receptor Modulators -- pharmacology
- Signal Transduction -- drug effects
- Tamoxifen -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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