A novel class of substituted spiro [quinazoline-2,1'-cyclohexane] derivatives as effective PPAR-1 inhibitors: molecular modeling, synthesis, cytotoxic and enzyme assay evaluation. [electronic resource]
Producer: 20130910Description: 687-708 p. digitalISSN:- 0001-6837
- Antineoplastic Agents -- chemical synthesis
- Benzamides -- pharmacology
- Binding Sites
- Breast Neoplasms -- enzymology
- Cell Proliferation
- Computer-Aided Design
- Cyclohexanes -- chemical synthesis
- Doxorubicin -- pharmacology
- Drug Design
- Enzyme Inhibitors -- chemical synthesis
- Female
- Humans
- MCF-7 Cells
- Molecular Docking Simulation
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- chemistry
- Protein Conformation
- Quinazolines -- chemical synthesis
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Publication Type: Comparative Study; Journal Article
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