CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway. [electronic resource]
Producer: 20131210Description: 2094-6 p. digitalISSN:- 1476-5551
- Adenine -- analogs & derivatives
- Antineoplastic Agents -- pharmacology
- Casein Kinase II -- antagonists & inhibitors
- Drug Synergism
- Hematologic Neoplasms -- drug therapy
- Humans
- Immunoglobulin G -- pharmacology
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Naphthyridines -- pharmacology
- Phenazines
- Piperidines
- Prognosis
- Purines -- pharmacology
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Quinazolinones -- pharmacology
- Receptors, Antigen, B-Cell -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Vidarabine -- analogs & derivatives
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Publication Type: Letter
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