Axons are injured by antigen-specific CD8(+) T cells through a MHC class I- and granzyme B-dependent mechanism. [electronic resource]
Producer: 20140505Description: 194-205 p. digitalISSN:- 1095-953X
- Animals
- Axons -- metabolism
- CD8 Antigens -- metabolism
- Cerebral Cortex -- cytology
- Embryo, Mammalian
- Gene Expression Regulation -- drug effects
- Granzymes -- genetics
- Histocompatibility Antigens Class I -- genetics
- Interferon-gamma -- pharmacology
- Lymphocyte Activation -- immunology
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Nerve Tissue Proteins -- metabolism
- Neuroglia -- cytology
- Neurons -- cytology
- Ovalbumin -- genetics
- Peptide Fragments -- pharmacology
- T-Lymphocytes, Cytotoxic -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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