The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. [electronic resource]
Producer: 20140407Description: 803-12 p. digitalISSN:- 1791-2423
- Animals
- Apoptosis -- drug effects
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Forkhead Box Protein M1
- Forkhead Transcription Factors -- biosynthesis
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Mice
- Oncogene Proteins, Fusion -- genetics
- Proto-Oncogene Protein c-fli-1 -- genetics
- RNA, Small Interfering
- RNA-Binding Protein EWS -- genetics
- Sarcoma, Ewing -- drug therapy
- Thiostrepton -- administration & dosage
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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