Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation. [electronic resource]
Producer: 20140422Description: 329-35 p. digitalISSN:- 1878-1705
- Active Transport, Cell Nucleus -- drug effects
- Aged
- Cell Nucleus -- metabolism
- Cells, Cultured
- Chondrocytes -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Hydroxamic Acids -- pharmacology
- Interleukin-1beta -- immunology
- Matrix Metalloproteinase 1 -- metabolism
- Matrix Metalloproteinase 13 -- metabolism
- Middle Aged
- NF-kappa B -- metabolism
- Nitric Oxide Synthase Type II -- metabolism
- Osteoarthritis -- drug therapy
- Phosphorylation
- Signal Transduction -- drug effects
- Tissue Inhibitor of Metalloproteinase-1 -- metabolism
- Vorinostat
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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