Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. [electronic resource]
Producer: 20131112Description: 2121-9 p. digitalISSN:- 1524-4636
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Atrial Natriuretic Factor -- pharmacology
- Calcium -- metabolism
- Calcium Channel Blockers -- pharmacology
- Capillary Permeability -- drug effects
- Cyclic GMP-Dependent Protein Kinase Type I -- deficiency
- Dose-Response Relationship, Drug
- Endothelial Cells -- drug effects
- HEK293 Cells
- Histamine -- pharmacology
- Histamine Antagonists -- pharmacology
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Male
- Mast Cells -- drug effects
- Membrane Proteins
- Mice
- Mice, Knockout
- Microvessels -- drug effects
- Phosphodiesterase 5 Inhibitors -- pharmacology
- Phosphoproteins -- genetics
- Phosphorylation
- Receptors, Atrial Natriuretic Factor -- genetics
- Signal Transduction -- drug effects
- TRPC Cation Channels -- deficiency
- TRPC6 Cation Channel
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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