Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. [electronic resource]
Producer: 20140213Description: 630-7 p. digitalISSN:- 1546-1696
- Animals
- Cell Cycle Proteins -- genetics
- Crizotinib
- Drug Approval
- Drug Interactions
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- Mice
- Molecular Chaperones -- metabolism
- Neoplasms -- drug therapy
- Phosphotransferases -- antagonists & inhibitors
- Protein Binding
- Protein Kinase Inhibitors -- therapeutic use
- Proto-Oncogene Proteins c-ets -- metabolism
- Pyrazoles -- therapeutic use
- Pyridines -- therapeutic use
- Receptor, trkC -- metabolism
- Repressor Proteins -- metabolism
- Substrate Specificity
- Xenograft Model Antitumor Assays
- ETS Translocation Variant 6 Protein
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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