Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. [electronic resource]
Producer: 20140130Description: e65267 p. digitalISSN:- 1932-6203
- Animals
- Base Sequence
- Cell Hypoxia
- Cell Proliferation
- Cell Survival
- Deoxyribonucleases, Type II Site-Specific -- chemistry
- Female
- Frameshift Mutation
- Gene Dosage
- Gene Knockout Techniques
- Genetic Engineering -- methods
- Glucokinase -- genetics
- Glycolysis
- HCT116 Cells
- Hexokinase -- genetics
- Humans
- Mice
- Mice, Nude
- Mitochondria -- metabolism
- Molecular Sequence Data
- Neoplasm Transplantation
- Oxidative Phosphorylation
- Oxygen Consumption
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Transcription Factors -- genetics
- Transcriptome
- Tumor Burden
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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