Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. [electronic resource]
Producer: 20150511Description: 1527-41 p. digitalISSN:- 1863-2661
- Age Factors
- Amyloid beta-Peptides -- metabolism
- Animals
- Animals, Newborn
- Cells, Cultured
- Choline O-Acetyltransferase -- metabolism
- Cholinergic Neurons -- drug effects
- Enzyme Inhibitors -- pharmacology
- Lysosomal-Associated Membrane Protein 1 -- metabolism
- Lysosomes -- drug effects
- Neurotoxins -- pharmacology
- Peptide Fragments -- metabolism
- Prosencephalon -- cytology
- Protein Transport -- drug effects
- Rats
- Receptor, Nerve Growth Factor -- metabolism
- Sodium Channel Blockers -- pharmacology
- Tetrodotoxin -- pharmacology
- Thapsigargin -- pharmacology
- Vesicular Transport Proteins -- metabolism
- rab GTP-Binding Proteins -- metabolism
- rab7 GTP-Binding Proteins
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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